Journal: Molecular Autism

Article Title: Beyond the three-chamber test: toward a multimodal and objective assessment of social behavior in rodents

doi: 10.1186/s13229-022-00521-6

Figure Lengend Snippet: Available programs used for USV analysis in rodents

Article Snippet: Mouse Ultrasonic Profile ExTraction (MUPET) , An open access MATLAB tool for data-driven analysis of USVs by measuring, learning, and comparing syllable types MUPET uses an automated and unsupervised algorithmic approach for the detection and clustering of syllable types summarized in the following features: Syllable detection by isolating and measuring spectro-temporal syllable variables, followed by analyzing overall vocalization features (syllable number, rate and duration, spectral density, and fundamental frequency) The application of unsupervised machine learning based on k-means clustering to build “syllable repertoire” from the dataset which includes up to several hundreds of the most represented syllable types based on spectral shape similarities within that dataset Similarity measurement between syllable types of two different repertoires using rank order comparisons in a manner that is frequency-independent Centroid-based (k-medoids) cluster analysis of syllable types from different syllable repertoires of different datasets to measure the frequency of use of different syllable types across conditions or strains and identify shared and unique shapes Provides automated time-stamps of syllable events for synchronized analysis with behavior The option for the user to control features regarding noise reduction, minimum and maximum syllable duration, minimum total and peak syllable energy, and the minimum inter-syllable interval needed to separate rapidly successive notes into distinct syllables Cannot detect USVs below 30 kHz [ ] , [ ] .

Techniques: Extraction, Software, Control

Journal: Expert review of medical devices

Article Title: Closed-loop control in insulin pumps for type-1 diabetes mellitus: safety and efficacy

doi: 10.1080/17434440.2020.1784724

Figure Lengend Snippet: Hybrid closed loop systems. (a) Medtronic 670G Hybrid Closed System with Guardian Link 3 transmitter and the COUNTOUR NEXT LINK blood glucose meter (reproduced with permission of Medtronic, Inc.) (b) Diabeloop system with DLBG1 Algorithm with Kaleido insullin patch-pump (reproduced with permission of Diabelop SA) (c) Omnipod Horizon Hybrid Closed Loop System (Insulet Crop., Acton, MA, USA) paired with a Dexcom G6 sensor (Dexcom, San Diego, CA, USA)(Copyrighted image used with permission. © 2019 Insulet Corporation. All rights reserved.) (d) CamAPS FX algorithm with Dexcom G6 sensor and Dana Diabecare RS Sooil insulin pump (Sooil Development, Seoul, Korea) (reproduced with permission of CamDiab Ltd.) (e) Tandem tslim X2 insulin pump (Tandem Diabetes Care, San Diego, CA, USA) paired with a Dexcom G6 Sensor (Dexcom, San Diego, CA, USA).

Article Snippet: All rights reserved.) (d) CamAPS FX algorithm with Dexcom G6 sensor and Dana Diabecare RS Sooil insulin pump (Sooil Development, Seoul, Korea) (reproduced with permission of CamDiab Ltd.) (e) Tandem tslim X2 insulin pump (Tandem Diabetes Care, San Diego, CA, USA) paired with a Dexcom G6 Sensor (Dexcom, San Diego, CA, USA). table ft1 table-wrap mode="anchored" t5 Table 1. caption a7 CamAPS FX MiniMed 670G System Tandem Control-IQ Regulatory approvals Age licensed for 1 year + 7 years + 14 years + Countries licensed in Europe USA & Europe USA & Europe Location of algorithm App-based Pump-integrated Pump-integrated Compatible with factory calibrated CGM Yes – Dexcom G6 No – regular finger-prick calibrations required Yes – Dexcom G6 Insulins licensed for Rapid- and ultra-rapid acting Rapid-acting Rapid-acting System features Parameters required for system setup TDD, weight TDD, weight, ICR, ISF, basal rates TDD, weight, ICR, ISF, basal rates Adaptive learning Overall, diurnal, meals Overall None Target type Treat-to-target: default 5.8mmol/L Treat-to-target: 6.7mmol/L Treat-to-range: 6.2–8.9mmol/L Adjustable glucose target Personalised target 4.4 – 11mmol/L; Personalised time-blocks Temporary target option of 8.3mmol/L Overnight target range 6.1–6.7mmol/L (Sleep Activity) Exercise target range 7.8–8.9mmol/L Active insulin time Automatically adjusted based on adaptive learning Personalised active insulin time of 2–8 hours Factory-set at 5 hours; not adjustable Automated correction bolus No No Yes, when glucose is predicted to be >10mmol/L and not in Sleep Activity Automode suspension No Yes No Automated data upload to cloud Diasend No No User features Phone-based bolusing Yes No No Activity mode Yes Yes Yes Boost mode Yes No No Remote glucose monitoring Yes – SMS alerts No Yes – live Followers Open in a separate window [CGM – continuous glucose monitoring; TDD – total daily dose; ICR – insulin-to-carbohydrate ratio; ISF – insulin sensitivity factor; Boost mode in CamAPS FX is user-initiated and intensifies algorithm-driven insulin delivery for use during periods of high glucose e.g. minor illness, pre-menstrual, growth hormone pulses etc.]

Techniques:

Journal: Expert review of medical devices

Article Title: Closed-loop control in insulin pumps for type-1 diabetes mellitus: safety and efficacy

doi: 10.1080/17434440.2020.1784724

Figure Lengend Snippet: Comparison of commercially available hybrid closed-loop systems.

Article Snippet: All rights reserved.) (d) CamAPS FX algorithm with Dexcom G6 sensor and Dana Diabecare RS Sooil insulin pump (Sooil Development, Seoul, Korea) (reproduced with permission of CamDiab Ltd.) (e) Tandem tslim X2 insulin pump (Tandem Diabetes Care, San Diego, CA, USA) paired with a Dexcom G6 Sensor (Dexcom, San Diego, CA, USA). table ft1 table-wrap mode="anchored" t5 Table 1. caption a7 CamAPS FX MiniMed 670G System Tandem Control-IQ Regulatory approvals Age licensed for 1 year + 7 years + 14 years + Countries licensed in Europe USA & Europe USA & Europe Location of algorithm App-based Pump-integrated Pump-integrated Compatible with factory calibrated CGM Yes – Dexcom G6 No – regular finger-prick calibrations required Yes – Dexcom G6 Insulins licensed for Rapid- and ultra-rapid acting Rapid-acting Rapid-acting System features Parameters required for system setup TDD, weight TDD, weight, ICR, ISF, basal rates TDD, weight, ICR, ISF, basal rates Adaptive learning Overall, diurnal, meals Overall None Target type Treat-to-target: default 5.8mmol/L Treat-to-target: 6.7mmol/L Treat-to-range: 6.2–8.9mmol/L Adjustable glucose target Personalised target 4.4 – 11mmol/L; Personalised time-blocks Temporary target option of 8.3mmol/L Overnight target range 6.1–6.7mmol/L (Sleep Activity) Exercise target range 7.8–8.9mmol/L Active insulin time Automatically adjusted based on adaptive learning Personalised active insulin time of 2–8 hours Factory-set at 5 hours; not adjustable Automated correction bolus No No Yes, when glucose is predicted to be >10mmol/L and not in Sleep Activity Automode suspension No Yes No Automated data upload to cloud Diasend No No User features Phone-based bolusing Yes No No Activity mode Yes Yes Yes Boost mode Yes No No Remote glucose monitoring Yes – SMS alerts No Yes – live Followers Open in a separate window [CGM – continuous glucose monitoring; TDD – total daily dose; ICR – insulin-to-carbohydrate ratio; ISF – insulin sensitivity factor; Boost mode in CamAPS FX is user-initiated and intensifies algorithm-driven insulin delivery for use during periods of high glucose e.g. minor illness, pre-menstrual, growth hormone pulses etc.]

Techniques: Activity Assay